Category Archives: Methadone

Opiate Withdrawal Symptoms

client77Those not familiar with opiate addiction may not readily grasp what it means to go through opiate withdrawal. For the addicted individual, he or she knows all too well how sick and uncomfortable it feels when withdrawal symptoms begin to surface.

Typical symptoms include diarrhea, muscle aches, cramps, fatigue, chills, runny nose, nausea & vomiting, sweating, shakes, sleeplessness, agitation, and depression. The duration of opiate withdrawal symptoms varies from person to person depending on the type of opiates used, amount, length of time, and method of use.

Some individuals may feel symptoms dissipate after just 1 or 2 days (obviously a preferable scenario). Others may feel withdrawal symptoms for weeks after last opioid use. Continued cravings for opiates may extend well beyond the disappearance of physical withdrawal sickness. This is due in part to structural changes which have occurred in the brain in which additional opiate receptors have been created along with a heightened sensitivity to the absence of opiates.

Cravings, like the other more prominent withdrawal symptoms, tend to fade over time as the body tries to restore an equilibrium. However, drug use urges can be brought on when an individual is exposed to triggers associated with past drug use. There are those opioid dependent persons who seem to never reach a normal equilibrium again, and who may benefit from long term methadone maintenance. This allows them to feel normal, and to achieve a higher level of functioning & comfort. Buprenorphine is now also used for long term maintenance although the vast majority of maintenance cases are achieved through methadone.

Baltimore Methadone Clinics

baltimoreIn reviewing the abundance of opioid treatment programs across the country, it was interesting to compare larger metropolitan cities with some of America's smaller, more rural towns. Typically, big cities have a higher concentration of methadone clinics and rural areas might have one or two programs.

One standout is the city of Baltimore, Maryland which currently provides 27 methadone clinics. By contrast, Brooklyn has 25. Brooklyn is the largest borough of New York City with a population of approximately 2.5 million people. Boston, obviously a densely populated metro city, has only five opioid treatment programs.

A positive development over the last decade was the emergence of more opioid treatment programs in rural America. Here is an example. Boone is a North Carolina college town of just over 14,000 people. Ten years ago they had no methadone programs. Today, they have two clinics, likely due in large part to the town's increased student population when Appalachian State University kicks into high gear each fall.

Historically, many opioid addicted individuals have had to travel great distances to become clients of a methadone treatment program. Thankfully, opioid treatment programs are becoming much more accessible. While not always readily accepted by local area residents, methadone clinics serve a critical need in the community. And their availability brings many benefits.

Buprenorphine and Suboxone in Opioid Addiction Treatment

methadoneblog4Suboxone® (a branded medication of Reckitt Benckiser Pharmaceuticals) is a relatively newer opioid replacement therapy consisting of a combination of buprenorphine and naloxone. Buprenorphine is the generic, active ingredient in Suboxone that provides extended relief from opioid withdrawal symptoms. Naloxone is an opioid antagonist that deters abuse of suboxone by injection.

Methadone and buprenorphine are the only two opioid medications which are FDA-approved for the treatment of opioid addiction. While they achieve the same end, they have significant differences. Buprenorphine can be administered in a physician's office, and is considered safer than methadone. However, buprenorphine is a "partial" opioid and provides little benefit beyond the maximum dose of 24 mg. This is sufficient for many opioid dependent persons and will provide substantial relief.

Methadone, by contrast, is more powerful and does not have the same ceiling effect of buprenorphine. Some clients find that they are more comfortable on methadone. It is not easy to predict which clients can be effectively maintained on buprenorphine. Some individuals have started on methadone for maintenance, but then later switched to buprenorphine to complete their medication taper.

Currently, Suboxone costs more than methadone. For this reason, many seeking opioid replacement therapy will choose methadone. There is some opinion that longer term opioid addicts tend to stabilize better on methadone over buprenorphine (Suboxone). In the end, the choice of which replacement medication to go with is best determined by the client and their physician. What is most important … is to seek help as soon as possible.

Methadone Diversion Control and Safety

lockboxMethadone clinics all have a medication diversion control policy. Methadone is a strong medication, and must be maintained in a secure location at all times. This becomes particularly important when a client earns methadone take home privileges.

With take home medication comes the responsibility of insuring that no one else has access to a client's methadone take home dose(s). This requires that each client provide a locked container of some type in which he or she will store their take home medication.

Each day's methadone dose is packaged & labeled separately. Upon receipt of take home doses from the clinic nurse, a client will collect & place all doses in their respective lock box container. Losing or misplacing take home doses is usually a violation of a clinic's take home agreement and can result in suspension of take home privileges.

While this may seem like a stiff penalty, it is good practice and helps to insure that all parties involved are taking necessary precautions. Methadone is safe when used properly, but can lead to serious medical emergencies if ingested by a child or non-tolerant user. Ultimately, each client must be responsible. And each clinic must take all available safeguards. The public depends on it, and regulatory authorities demand it.

Methadone Treatment Across America

methadoneclient4A 2008 study, funded through SAMHSA, examined the characteristics of 1,056 Opioid Treatment Programs across the United States. At that time, there were 270,881 opioid treatment clients enrolled in an OTP clinic and receiving either methadone or buprenorphine for maintenance therapy.

Of the 270,881 OTP clients, 98.5% were receiving methadone with the remainder receiving buprenorphine. The study also looked at payment methods used for services in the various OTP clinics and found that self-payment, private insurance, and Medicaid were the three most prevalent forms of payment.

Approximately 33% to 53% of Opioid Treatment Clinics had contracts with LME's (Local Management Entities that use state funds to subsidize treatment). Clinics which offered mixed substance abuse & mental health services were more apt to receive LME state funding support for low income clients.

In closing, an updated 2009 SAMHSA study estimated there were 399,000 individuals in the U.S. who were dependent on or abused heroin, and 1,900,000 persons who were dependent on or abused prescription pain medication. With over 2 million Americans "at risk" and suffering with an opioid problem, methadone treatment programs are providing a valuable intervention on both a personal and societal level.